About Me

I am an applied mathematician working in quantitative systems pharmacology (QSP) and pharmacometrics. I use mathematical, statistical, and computational tools to advance the pre-clinical and clinical development of new therapeutics.

• Secretary, SIAM Life Sciences Activity Group, 2024–
• Senior Research Scientist, Development, AbCellera, 2023–
• Scientist II, Systems Biology, Notch Therapeutics, 2021–2023
• NSERC Postdoctoral Research Fellow, 2018–2021
  Department of Physics and Astronomy, Vanderbilt University
  Mentor: William Holmes

Education

• Ph.D. in Mathematics, 2018
  University of British Columbia
  Mentor: Leah Edelstein-Keshet
• M.Sc. in Applied Mathematics, 2014
  University of Alberta
  Mentor: Gerda de Vries
• B.Sc. in Honors Mathematics, 2012
  University of Alberta

Publications
* denotes equal contributions

1. D. C. Kirouac, C. Zmurchok, and & D. Morris. Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics. npj Systems Biology and Applications, 10, 31, 2024. https://doi.org/10.1038/s41540-024-00355-3
2. D. C. Kirouac, C. Zmurchok*, A. Deyati*, J. Sicherman, P. W. Zandstra, and C. Bond. Deconvolution of clinical variance in CAR-T cell pharmacology and response. Nature Biotechnology, 41, 1606‐1617, 2023. https://doi.org/10.1038/s41587-023-01687-x

   
3. C. Zmurchok, M. Sahota, W. Nagata, and E. N. Cytrynbaum, Local and Global Bifurcations in a Mechanochemical ODE Model for Cell Behavior. Differential Equations and Dynamical Systems, 2023. https://doi.org/10.1007/s12591-023-00636-z
4. C. Zmurchok, W. R. Holmes, Biophysical Models of PAR Cluster Transport by Cortical Flow in C. elegans Early Embryogenesis. Bulletin of Mathematical Biology, 84(40), 2022. https://doi.org/10.1007/s11538-022-00997-6
5. T. L. Stepien*, C. Zmurchok*, J. B. Hengenius, R. M. C. Rivera, M. R. D'Orsogna, and A. E. Lindsay. Moth mating: modeling female pheromone calling and male navigational strategies to optimize reproductive success. Applied Sciences, 10(18):6543, 2020. https://doi.org/10.3390/app10186543
6. C. Zmurchok*, J. Collette*, V. Rajagopal, and W. R. Holmes. Membrane tension can enhance adaptation to maintain polarity of migrating cells. Biophysical Journal, 119(8):1617-1629, 2020. https://doi.org/10.1016/j.bpj.2020.08.035
7. C. Zmurchok and W. R. Holmes. Simple Rho GTPase dynamics generate a complex regulatory landscape associated with cell shape. Biophysical Journal, 118(6):1438-1454, 2020. https://doi.org/10.1016/j.bpj.2020.01.035
8. C. Zmurchok and G. de Vries. Direction-dependent interaction rules enrich pattern formation in an individual-based model of collective behavior. PLOS ONE, 13(6):e0198550, 2018. http://doi.org/10.1371/journal.pone.0198550
9. C. Zmurchok, D. Bhaskar, and L. Edelstein-Keshet. Coupling mechanical tension and GTPase signaling to generate cell and tissue dynamics. Physical Biology, 15(4):046004, 2018. https://doi.org/10.1088/1478-3975/aab1c0
10. C. Zmurchok, T. Small, M. J. Ward, and L. Edelstein-Keshet. Application of quasi-steady-state methods to nonlinear models of intracellular transport by molecular motors. Bulletin of Mathematical Biology, 79(9):1923‐1978, 2017. https://doi.org/10.1007/s11538-017-0314-1
11. H. Knutsdottir, C. Zmurchok, D. Bhaskar, E. Palsson, D. Dalle Nogare, A. B. Chitnis, and L. Edelstein-Keshet. Polarization and migration in the zebrafish posterior lateral line system. PLOS Computational Biology, 13(4):e1005451, 2017. https://doi.org/10.1371/journal.pcbi.1005451

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